The cobas e 411 is an automated immunoassay analyzer made by Roche Diagnostics. It belongs to the cobas e series and is suited for medium-sized labs. It offers a reliable and flexible option for immunoassay testing. It is well-known for its fast processing, easy use, and ability to test for infectious diseases, heart markers, hormones, tumor markers, and more.
Key Features of the cobas e 411:
- Compact and User-Friendly:
- Small footprint, making it suitable for labs with limited space.
- Intuitive user interface with a large color touchscreen for easy operation and test management.
- High-Throughput Testing:
- Up to 86 tests per hour for faster turnaround time.
- Continuous loading and unloading for improved workflow and high sample throughput.
- Wide Assay Menu:
- Supports a broad range of tests across different medical disciplines, including hormones, tumor markers, infectious diseases, and cardiac markers.
- It offers over 70 assays available through Roche’s Elecsys immunoassay technology.
- Flexible Sample Types:
- Capable of analyzing serum, plasma, and urine samples.
- The analyzer can process a variety of sample sizes with small volumes.
- Fully Automated:
- Automated test processing, including reagent management, calibration, and result calculation.
- Automatic sample dilution and pre-analytical handling, reducing the need for manual intervention.
- Electrochemiluminescence Technology (ECL):
- Uses Electrochemiluminescence (ECL) detection, which is a highly sensitive technology for immunoassays. This technology ensures high specificity and reliable results even for low analyte concentrations.
- Low Sample Volume:
- Requires a small sample volume, usually 20-50 µL per test, making it ideal for pediatric or critically ill patients.
- Onboard Reagent Management:
- Automatic reagent replenishment and onboard cooling for reagents to ensure that they remain at optimal temperatures, increasing their shelf life and performance.
- Quality Control Integration:
- Continuous QC monitoring with built-in quality assurance tools for validation, including automated calibration and reagent checks.
- Supports external control samples and automatic result interpretation to ensure reliable results.
- Data Connectivity:
- Bidirectional communication with Laboratory Information Management Systems (LIMS) via standard protocols like HL7, ensuring smooth integration into laboratory workflows.
- Remote access for troubleshooting and system diagnostics.
Specifications of the cobas e 411:
| Parameter | Details |
|---|---|
| Assay Throughput | Up to 86 tests per hour |
| Sample Volume per Test | 20-50 µL per test (depending on assay type) |
| Test Menu | Over 70 assays for a wide range of analytes (e.g., hormones, cardiac markers, tumor markers) |
| Sample Types | Serum, Plasma, Urine |
| Channels | Single channel |
| Reagent Capacity | 20 reagent positions (for various immunoassays) |
| Calibration | Automated calibration with ECL technology |
| QC & Error Monitoring | Built-in quality control (QC) system with automatic checks, sample/reagent integrity verification |
| Operating Temperature | 15°C to 30°C (59°F to 86°F) |
| Dimensions | W x D x H: 435 x 445 x 290 mm |
| Weight | Approx. 15.5 kg (34 lbs) |
| Display | 8.4-inch color touchscreen |
| Connectivity | Bidirectional communication with LIMS (HL7, LIS) |
| Power Supply | 100-240V, 50/60Hz |
| Humidity | 20% to 80% non-condensing |
Additional Characteristics:
- Sample & Reagent Management:
- Random access for uninterrupted sample testing.
- Automatic identification and tracking of reagents, reducing the chance of errors.
- Flexibility:
- Can be configured to meet the needs of different clinical environments, offering both routine and specialty testing.
- Supports a range of immunoassay applications including endocrinology, cardiology, infectious diseases, and oncology.
- Space-Efficient:
- The cobas e 411 is specifically designed for smaller laboratories or for environments where space is at a premium.
- Ease of Maintenance:
- Minimal routine maintenance required with easy-to-replace reagent packs and low-cost consumables.
- Data Management and Security:
- Offers full data traceability, audit trails, and secure result storage.
- Can export results to external systems or cloud storage via network connections.
Applications:
- Endocrinology: Thyroid hormones, reproductive hormones, adrenal hormones, and more.
- Cardiology: Cardiac markers such as troponin, BNP, and CK-MB.
- Oncology: Tumor markers like PSA, CA-125, and AFP.
- Infectious Diseases: Immunoassays for HIV, hepatitis, Zika virus, etc.
- Pregnancy and Fertility Testing: HCG, FSH, LH, and other fertility-related assays.
Conclusion:
The cobas e 411 is a compact, automated immunoassay analyzer that performs many tests with high sensitivity, accuracy, and reliability. It is ideal for medium-sized labs or labs with limited space, providing flexibility, ease of use, and fast results while maintaining quality.
