The cobas e 411 is a fully automated immunoassay analyzer developed by Roche Diagnostics. It is part of the cobas e series and is designed for medium-sized laboratories, offering a versatile and reliable solution for immunoassay testing. It is especially popular for its high throughput, flexibility, and ease of use in clinical diagnostics, including tests for infectious diseases, cardiac markers, hormones, tumor markers, and more.
Key Features of the cobas e 411:
- Compact and User-Friendly:
- Small footprint, making it suitable for labs with limited space.
- Intuitive user interface with a large color touchscreen for easy operation and test management.
- High-Throughput Testing:
- Up to 86 tests per hour for faster turnaround time.
- Continuous loading and unloading for improved workflow and high sample throughput.
- Wide Assay Menu:
- Supports a broad range of tests across different medical disciplines, including hormones, tumor markers, infectious diseases, and cardiac markers.
- It offers over 70 assays available through Roche’s Elecsys immunoassay technology.
- Flexible Sample Types:
- Capable of analyzing serum, plasma, and urine samples.
- The analyzer can process a variety of sample sizes with small volumes.
- Fully Automated:
- Automated test processing, including reagent management, calibration, and result calculation.
- Automatic sample dilution and pre-analytical handling, reducing the need for manual intervention.
- Electrochemiluminescence Technology (ECL):
- Uses Electrochemiluminescence (ECL) detection, which is a highly sensitive technology for immunoassays. This technology ensures high specificity and reliable results even for low analyte concentrations.
- Low Sample Volume:
- Requires a small sample volume, usually 20-50 µL per test, making it ideal for pediatric or critically ill patients.
- Onboard Reagent Management:
- Automatic reagent replenishment and onboard cooling for reagents to ensure that they remain at optimal temperatures, increasing their shelf life and performance.
- Quality Control Integration:
- Continuous QC monitoring with built-in quality assurance tools for validation, including automated calibration and reagent checks.
- Supports external control samples and automatic result interpretation to ensure reliable results.
- Data Connectivity:
- Bidirectional communication with Laboratory Information Management Systems (LIMS) via standard protocols like HL7, ensuring smooth integration into laboratory workflows.
- Remote access for troubleshooting and system diagnostics.
Specifications of the cobas e 411:
| Parameter | Details |
|---|---|
| Assay Throughput | Up to 86 tests per hour |
| Sample Volume per Test | 20-50 µL per test (depending on assay type) |
| Test Menu | Over 70 assays for a wide range of analytes (e.g., hormones, cardiac markers, tumor markers) |
| Sample Types | Serum, Plasma, Urine |
| Channels | Single channel |
| Reagent Capacity | 20 reagent positions (for various immunoassays) |
| Calibration | Automated calibration with ECL technology |
| QC & Error Monitoring | Built-in quality control (QC) system with automatic checks, sample/reagent integrity verification |
| Operating Temperature | 15°C to 30°C (59°F to 86°F) |
| Dimensions | W x D x H: 435 x 445 x 290 mm |
| Weight | Approx. 15.5 kg (34 lbs) |
| Display | 8.4-inch color touchscreen |
| Connectivity | Bidirectional communication with LIMS (HL7, LIS) |
| Power Supply | 100-240V, 50/60Hz |
| Humidity | 20% to 80% non-condensing |
Additional Characteristics:
- Sample & Reagent Management:
- Random access for uninterrupted sample testing.
- Automatic identification and tracking of reagents, reducing the chance of errors.
- Flexibility:
- Can be configured to meet the needs of different clinical environments, offering both routine and specialty testing.
- Supports a range of immunoassay applications including endocrinology, cardiology, infectious diseases, and oncology.
- Space-Efficient:
- The cobas e 411 is specifically designed for smaller laboratories or for environments where space is at a premium.
- Ease of Maintenance:
- Minimal routine maintenance required with easy-to-replace reagent packs and low-cost consumables.
- Data Management and Security:
- Offers full data traceability, audit trails, and secure result storage.
- Can export results to external systems or cloud storage via network connections.
Applications:
- Endocrinology: Thyroid hormones, reproductive hormones, adrenal hormones, and more.
- Cardiology: Cardiac markers such as troponin, BNP, and CK-MB.
- Oncology: Tumor markers like PSA, CA-125, and AFP.
- Infectious Diseases: Immunoassays for HIV, hepatitis, Zika virus, etc.
- Pregnancy and Fertility Testing: HCG, FSH, LH, and other fertility-related assays.
Conclusion:
The cobas e 411 is a versatile, automated immunoassay analyzer with a compact design that can deliver a broad range of immunoassay tests with high sensitivity, accuracy, and reliability. It is particularly suited for medium-sized labs or those with space constraints, offering flexibility, ease of use, and high throughput while ensuring high-quality results.
